Sen1 architecture: RNA-DNA hybrid resolution, autoregulation, and insights into SETX inactivation in AOA2.

Appel, C Denise; Bermek, Oya; Dandey, Venkata P; Wood, Makayla; Viverette, Elizabeth; Williams, Jason G; Bouvette, Jonathan; Riccio, Amanda A; Krahn, Juno M; Borgnia, Mario J; Williams, R Scott

Appel, C Denise; Bermek, Oya; Dandey, Venkata P; Wood, Makayla; Viverette, Elizabeth; Williams, Jason G; Bouvette, Jonathan; Riccio, Amanda A; Krahn, Juno M; Borgnia, Mario J; Williams, R Scott.

Afiliação

Appel CD; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Bermek O; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Dandey VP; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Wood M; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Viverette E; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Williams JG; Epigenetics and Stem Cell Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Bouvette J; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Riccio AA; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Krahn JM; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Borgnia MJ; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA.
Williams RS; Genome Integrity and Structural Biology Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC 27709, USA. Electronic address: williamsrs@niehs.nih.gov.

Mol Cell ; 83(20): 3692-3706.e5, 2023 10 19.

Article em En | MEDLINE | ID: mdl-37832548

Assuntos

Doenças Neurodegenerativas; RNA; Humanos; RNA/genética; Microscopia Crioeletrônica; RNA Helicases/genética; RNA Helicases/química; Enzimas Multifuncionais/genética; DNA/genética; Homeostase; DNA Helicases/genética

Palavras-chave

DNA repair; Helicase; R-loop; RNA-DNA hybrid; SETX; SF1B; Sen1; X-ray crystallography; cryo-EM; senataxin; transcription

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA / Doenças Neurodegenerativas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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