The many paths to artemisinin resistance in Plasmodium falciparum.
Trends Parasitol
; 39(12): 1060-1073, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-37833166
ABSTRACT
Emerging resistance against artemisinin (ART) poses a major challenge in controlling malaria. Parasites with mutations in PfKelch13, the major marker for ART resistance, are known to reduce hemoglobin endocytosis, induce unfolded protein response (UPR), elevate phosphatidylinositol-3-phosphate (PI3P) levels, and stimulate autophagy. Nonetheless, PfKelch13-independent resistance is also reported, indicating extensive complementation by reconfiguration in the parasite metabolome and transcriptome. These findings implicate that there may not be a single 'universal identifier' of ART resistance. This review sheds light on the molecular, transcriptional, and metabolic pathways associated with ART resistance, while also highlighting the interplay between cellular heterogeneity, environmental stress, and ART sensitivity.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Malária Falciparum
/
Artemisininas
/
Antimaláricos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article