ß-Sitosterol Suppresses Lipopolysaccharide-Induced Inflammation and Lipogenesis Disorder in Bovine Mammary Epithelial Cells.
Int J Mol Sci
; 24(19)2023 Sep 27.
Article
em En
| MEDLINE
| ID: mdl-37834091
ABSTRACT
ß-sitosterol, a natural plant steroid, has been shown to promote anti-inflammatory and antioxidant activities in the body. In this study, ß-sitosterol was used to protect against lipopolysaccharide (LPS)-induced cell damage in bovine mammary epithelial cells, which are commonly studied as a cell model of mammary inflammatory response and lipogenesis. Results showed that treatment with a combination of LPS and ß-sitosterol significantly reduced oxidative stress and inflammation, while increasing the expression of anti-apoptotic proteins and activating the hypoxia-inducible factor-1(HIF-1α)/mammalian target of rapamycin(mTOR) signaling pathway to inhibit apoptosis and improve lipid synthesis-related gene expression. Our finding suggests that ß-sitosterol has the potential to alleviate inflammation in the mammary gland.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Lipopolissacarídeos
/
Lipogênese
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article