Pan-Cancer Analysis of Patient Tumor Single-Cell Transcriptomes Identifies Promising Selective and Safe Chimeric Antigen Receptor Targets in Head and Neck Cancer.

Madan, Sanna; Sinha, Sanju; Chang, Tiangen; Gutkind, J Silvio; Cohen, Ezra E W; Schäffer, Alejandro A; Ruppin, Eytan

Madan, Sanna; Sinha, Sanju; Chang, Tiangen; Gutkind, J Silvio; Cohen, Ezra E W; Schäffer, Alejandro A; Ruppin, Eytan.

Afiliação

Madan S; Cancer Data Science Laboratory, National Cancer Institute, Bethesda, MD 20892, USA.
Sinha S; Department of Computer Science, University of Maryland, College Park, MD 20742, USA.
Chang T; Cancer Data Science Laboratory, National Cancer Institute, Bethesda, MD 20892, USA.
Gutkind JS; Cancer Data Science Laboratory, National Cancer Institute, Bethesda, MD 20892, USA.
Cohen EEW; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.
Schäffer AA; Department of Pharmacology, University of California San Diego, La Jolla, CA 92093, USA.
Ruppin E; Moores Cancer Center, University of California San Diego, La Jolla, CA 92093, USA.

Cancers (Basel) ; 15(19)2023 Oct 08.

Article em En | MEDLINE | ID: mdl-37835579

Palavras-chave

CAR-T; cell surface targets; clinical trials; glioblastoma; head and neck cancer; immunoreceptors; immunotherapy; single-cell RNA sequencing; solid tumors

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article