Metformin potentiates immunosuppressant activity and adipogenic differentiation of human umbilical cord-mesenchymal stem cells.

Bajetto, Adriana; Pattarozzi, Alessandra; Sirito, Rodolfo; Barbieri, Federica; Florio, Tullio

Bajetto, Adriana; Pattarozzi, Alessandra; Sirito, Rodolfo; Barbieri, Federica; Florio, Tullio.

Afiliação

Bajetto A; Section of Pharmacology, Department of Internal Medicine, University of Genova, 16132 Genova, Italy.
Pattarozzi A; Section of Pharmacology, Department of Internal Medicine, University of Genova, 16132 Genova, Italy.
Sirito R; Section of Obstetrics and Gynaecology, International Evangelical Hospital, 16122 Genova, Italy.
Barbieri F; Section of Pharmacology, Department of Internal Medicine, University of Genova, 16132 Genova, Italy.
Florio T; Section of Pharmacology, Department of Internal Medicine, University of Genova, 16132 Genova, Italy; IRCCS, Ospedale Policlinico San Martino, 16132 Genova, Italy. Electronic address: tullio.florio@unige.it.

Int Immunopharmacol ; 124(Pt B): 111078, 2023 Nov.

Article em En | MEDLINE | ID: mdl-37844465

Assuntos

Células-Tronco Mesenquimais; Metformina; Humanos; Meios de Cultivo Condicionados/metabolismo; Imunossupressores/farmacologia; Leucócitos Mononucleares; Metformina/farmacologia; PPAR gama/metabolismo; Diferenciação Celular/fisiologia; Cordão Umbilical; Inflamação/metabolismo; Células-Tronco Mesenquimais/metabolismo; Células Cultivadas

Palavras-chave

Adipogenesis; COX-2; Cytokines; Inflammation; Mesenchymal stem cells; Metformin

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Células-Tronco Mesenquimais / Metformina Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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