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Liraglutide treatment for the prevention of glucose tolerance deterioration in women with prior gestational diabetes mellitus: A 52-week randomized controlled clinical trial.
Foghsgaard, Signe; Vedtofte, Louise; Andersen, Emilie S; Bahne, Emilie; Andreasen, Camilla; Sørensen, Anne L; Forman, Julie L; Mathiesen, Elisabeth R; Svare, Jens A; Clausen, Tine D; Damm, Peter; Holst, Jens J; Knop, Filip K; Vilsbøll, Tina.
Afiliação
  • Foghsgaard S; Clinical Research, Steno Diabetes Center Copenhagen, University of Copenhagen, Herlev, Denmark.
  • Vedtofte L; Department of Gynaecology and Obstetrics, Herlev Hospital, University of Copenhagen, Herlev, Denmark.
  • Andersen ES; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Bahne E; Clinical Research, Steno Diabetes Center Copenhagen, University of Copenhagen, Herlev, Denmark.
  • Andreasen C; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Sørensen AL; Clinical Research, Steno Diabetes Center Copenhagen, University of Copenhagen, Herlev, Denmark.
  • Forman JL; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Mathiesen ER; Clinical Research, Steno Diabetes Center Copenhagen, University of Copenhagen, Herlev, Denmark.
  • Svare JA; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Clausen TD; Clinical Research, Steno Diabetes Center Copenhagen, University of Copenhagen, Herlev, Denmark.
  • Damm P; Center for Clinical Metabolic Research, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark.
  • Holst JJ; Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
  • Knop FK; Department of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark.
  • Vilsbøll T; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
Diabetes Obes Metab ; 26(1): 201-214, 2024 Jan.
Article em En | MEDLINE | ID: mdl-37846555
ABSTRACT

AIM:

We investigated the effect of 52-week treatment with liraglutide, a glucagon-like peptide 1 receptor agonist, on glucose tolerance and incretin effect in women with previous gestational diabetes mellitus (pGDM). MATERIALS AND

METHODS:

Women with overweight/obesity and pGDM were randomized to once daily subcutaneous liraglutide 1.8 mg or placebo for 52 weeks. Participants underwent oral glucose tolerance test (OGTT) and isoglycaemic intravenous glucose infusion at baseline and at 52 weeks, and an additional OGTT after the drug wash-out.

RESULTS:

In total, 104 women [age mean ± SD, 38 ± 5 years; fasting plasma glucose (FPG) 5.5 ± 0.4 mmol/L; glycated haemoglobin (HbA1c) 33 ± 4 mmol/mol, bodyweight 88.2 ± 14.8 kg, body mass index 31.1 ± 4.3 kg/m2 ] were assigned to liraglutide (n = 49) or placebo (n = 55). Estimated treatment difference (ETD) for area under curve during OGTT was -173 (95% confidence interval -250 to -97) mmol/L × min, p < .0001, but after wash-out the difference disappeared [ETD 58 (-30 to 146) mmol/L × min, p = .536]. Liraglutide reduced FPG [ETD -0.2 (-0.4 to -0.1) mmol/L, p = .018], HbA1c [-2.2 (-3.5 to -0.8) mmol/mol, p = .018] and bodyweight [-3.9 (-6.2 to -1.6) kg, p = .012]. No change in the incretin effect was observed. The number of women with prediabetes was reduced from 64% to 10% with liraglutide vs. 50% with placebo [adjusted odds ratio 0.10 (0.03-0.32), p = .002].

CONCLUSIONS:

Treatment with liraglutide for 52 weeks improved glucose tolerance, FPG, HbA1c and bodyweight in women with overweight/obesity and pGDM. Progression to prediabetes while on drug was markedly reduced, but after a 1-week drug wash-out, the effect was lost.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Diabetes Gestacional / Diabetes Mellitus Tipo 2 Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Estado Pré-Diabético / Diabetes Gestacional / Diabetes Mellitus Tipo 2 Limite: Adult / Female / Humans / Pregnancy Idioma: En Ano de publicação: 2024 Tipo de documento: Article