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2-λ5-Phosphaquinolin-2-ones as Non-cytotoxic, Targetable, and pH-Stable Fluorophores.
Bard, Jeremy P; Bolton, Sarah G; Howard, Holden J; McNeill, J Nolan; de Faria, Thaís P; Zakharov, Lev N; Johnson, Darren W; Pluth, Michael D; Haley, Michael M.
Afiliação
  • Bard JP; Department of Chemistry & Biochemistry and the Materials Science Institute, University of Oregon, Eugene, Oregon 97403-1253, United States.
  • Bolton SG; Department of Chemistry, Washington College, Chestertown, Maryland 21620-1438, United States.
  • Howard HJ; Department of Chemistry & Biochemistry and the Materials Science Institute, University of Oregon, Eugene, Oregon 97403-1253, United States.
  • McNeill JN; Department of Chemistry & Biochemistry and the Materials Science Institute, University of Oregon, Eugene, Oregon 97403-1253, United States.
  • de Faria TP; Department of Chemistry & Biochemistry and the Materials Science Institute, University of Oregon, Eugene, Oregon 97403-1253, United States.
  • Zakharov LN; Department of Chemistry & Biochemistry and the Materials Science Institute, University of Oregon, Eugene, Oregon 97403-1253, United States.
  • Johnson DW; CAMCOR, University of Oregon, Eugene, Oregon 97403-1433, United States.
  • Pluth MD; Department of Chemistry & Biochemistry and the Materials Science Institute, University of Oregon, Eugene, Oregon 97403-1253, United States.
  • Haley MM; Department of Chemistry & Biochemistry and the Materials Science Institute, University of Oregon, Eugene, Oregon 97403-1253, United States.
J Org Chem ; 88(21): 15516-15522, 2023 11 03.
Article em En | MEDLINE | ID: mdl-37852231
ABSTRACT
Several phosphaquinolinone derivatives have been synthesized and characterized to explore their usefulness in the realm of cell imaging. Solution-state photophysical properties in both aqueous and organic solutions were collected for these derivatives. Additionally, CCK-8 cell viability assays and fluorescent imaging in HeLa cells incubated with the new heterocyclic derivatives show evidence of favorable cell permeability, cell viability, and moderate intracellular localization when appended with the well-known morpholine targeting motif.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Água / Corantes Fluorescentes Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Água / Corantes Fluorescentes Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article