Locoregional therapy containing surgery in metastatic breast cancer: Systematic review and meta-analysis.
Surgeon
; 22(1): 43-51, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-37858431
ABSTRACT
INTRODUCTION:
The role of locoregional therapy (LRT) containing surgery and systematic therapy in metastatic breast cancer patients remains controversial. This study investigated the effect of LRT in patients who were initially diagnosed with metastatic breast cancer (MBC) on overall survival (OS), locoregional progression-free survival (PFS), and distant systemic PFS.METHODS:
The related keywords were searched in MEDLINE/PubMed, SCOPUS, and Web of Science databases up to August 15th, 2022. Hazard ratios (HR) with 95% confidence intervals (CIs) were pooled by the random-effects model.RESULTS:
Seven articles with 1626 participants compared LRT with only systemic therapy (ST) for patients with de novo MBC. LRT did not improve (p = 0.28) OS compared to ST (HR 0.83, 95% CI 0.60, 1.16). LRT significantly improved locoregional PFS outcomes compared to ST (HR 0.31, 95% CI 0.15, 0.60, p = 0.001). LRT significantly (p = 0.001) improved OS in patients with solitary bone metastases (HR 0.48; 95% CI 0.35-0.67).CONCLUSION:
LRT improves locoregional PFS. Furthermore, LRT improves OS in patients with solitary bone metastases.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
Tipo de estudo:
Systematic_reviews
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article