α2C-Adrenergic Receptor Blockade Inhibits Langendorff-Isolated Rat Heart Work.
Bull Exp Biol Med
; 175(5): 612-615, 2023 Sep.
Article
em En
| MEDLINE
| ID: mdl-37864587
ABSTRACT
We studied the effect of selective α2C-adrenergic receptor antagonist JP-1302 in concentrations of 10-9-10-6 M on inotropy, chronotropy, and coronary flow in the Langendorff-isolated rat heart. JP-1302 in all studied concentrations decreased the left-ventricular myocardium force contraction, HR, and coronary flow. The maximum inotropic, chronotropic, and vascular effects were observed when the antagonist was applied to the perfused solution in a concentration of 10-7 M. The least pronounced decrease in the studied parameters was observed at JP-1302 concentrations of 10-8 and 10-9 M. The obtained data indicate the participation of this subtype of α2-adrenergic receptors in the regulation of activity of isolated adult rats heart.
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MEDLINE
Assunto principal:
Ventrículos do Coração
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Miocárdio
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article