Elucidating the toxicity mechanisms of organophosphate esters by adverse outcome pathway network.
Arch Toxicol
; 98(1): 233-250, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37864630
ABSTRACT
With the widespread use of organophosphate esters (OPEs), the accumulation and toxicity effect of OPEs in biota are attracting more and more concern. In order to clarify the mechanism of toxicity of OPEs to organisms, this study reviewed the OPEs toxicity and systematically identified the mechanism of OPEs toxicity under the framework of adverse outcome pathway (AOP). OPEs were divided into three groups (alkyl-OPEs, aryl-OPEs, and halogenated-OPEs) and biota was divided into aquatic organism and mammals. The results showed that tris(1,3-dichloro-2-propyl) phosphate (TDCIPP) and triphenyl phosphate (TPHP) mainly caused neurotoxicity, reproductive, and hepatotoxicity in different mechanisms. According to the constructed AOP network, the toxicity mechanism of OPEs on aquatic organisms and mammals is different, which is mainly attributed to the different biological metabolic systems of aquatic organisms and mammals. Interestingly, our results indicate that the toxicity effect of the three kinds of OPEs on aquatic organisms is different, while there was no obvious difference in the mechanism of toxicity of OPEs on mammals. This study provides a theoretical basis for OPEs risk assessment in the future.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Retardadores de Chama
/
Rotas de Resultados Adversos
Limite:
Animals
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article