Neonatal per- and polyfluoroalkyl substance exposure in relation to retinoblastoma.
Environ Res
; 240(Pt 2): 117435, 2024 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-37866539
ABSTRACT
BACKGROUND:
Neonatal per- and polyfluoroalkyl substance (PFAS) exposure can disrupt hormonal homeostasis and induce neuro- and immunotoxicity in children. In this exploratory study, we investigated associations between PFAS levels in neonatal dried blood spots and retinoblastoma risk. MATERIALS ANDMETHODS:
This study included 501 retinoblastoma cases born from 1983 to 2011 and 899 controls frequency-matched by birth year (201 matching ratio), born to 755 US-born and 366 Mexico-born mothers in California. Perfluorooctanesulfonic acid (PFOS), perflurooctanoic acid (PFOA), and perfluorononanoic acid (PFNA) feature intensities were identified from neonatal blood spots from California newborn Genetic Disease Screening Program. Using logistic regression, we assessed whether an interquartile range (IQR) increase of PFAS levels or having above-mean levels of PFAS in blood affects retinoblastoma risk overall or its subtypes (i.e., unilateral, bilateral). We assessed children of US-born and Mexico-born mothers, separately. RESULTS ANDDISCUSSION:
Among all children, above-mean PFOS levels at birth increased the odds of retinoblastoma overall by 29% (95% Confidence Interval (CI) 1.00, 1.67) and unilateral retinoblastoma by 42% (95% CI 1.03, 1.97). For children of Mexico-born mothers, we estimated the highest odds of retinoblastoma overall (adjusted odds ratio (aOR) 1.67; 95% CI 1.06, 2.66) and bilateral retinoblastoma (aOR 2.06; 95% CI 1.12, 3.92) with above-mean PFOS levels. Among children of US-born mothers, higher PFOS levels increased the odds of unilateral retinoblastoma by 15% (95% CI 0.99, 1.35) for each IQR increase and by 71% among children with above-mean PFOS levels (95% CI 1.04, 2.90). In addition, for children of US-born mothers, PFOA increased the odds of retinoblastoma overall (aOR 1.41; 95% CI 1.00, 2.02 for above-mean levels, aOR 1.06; 95% CI 0.98, 1.16 per IQR increase). PFNA was not associated with retinoblastoma risk.CONCLUSIONS:
Our results suggested that PFOS and PFOA might contribute to retinoblastoma risk in children born in California.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Retinoblastoma
/
Neoplasias da Retina
/
Fluorocarbonos
Limite:
Child
/
Humans
/
Newborn
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article