The molecular basis of dapsone activation of CYP2C9-catalyzed nonsteroidal anti-inflammatory drug oxidation.

Nair, Pramod C; Burns, Kushari; Chau, Nuy; McKinnon, Ross A; Miners, John O

Nair, Pramod C; Burns, Kushari; Chau, Nuy; McKinnon, Ross A; Miners, John O.

Afiliação

Nair PC; Department of Clinical Pharmacology, Flinders University College of Medicine and Public Health, Flinders Medical Centre, Bedford Park, South Australia, Australia; FHMRI Cancer Program, Flinders Health and Medical Research Institute, Flinders University College of Medicine and Public Health, Flinders
Burns K; Department of Clinical Pharmacology, Flinders University College of Medicine and Public Health, Flinders Medical Centre, Bedford Park, South Australia, Australia.
Chau N; Department of Clinical Pharmacology, Flinders University College of Medicine and Public Health, Flinders Medical Centre, Bedford Park, South Australia, Australia.
McKinnon RA; FHMRI Cancer Program, Flinders Health and Medical Research Institute, Flinders University College of Medicine and Public Health, Flinders Medical Centre, Bedford Park, South Australia, Australia.
Miners JO; Department of Clinical Pharmacology, Flinders University College of Medicine and Public Health, Flinders Medical Centre, Bedford Park, South Australia, Australia; FHMRI Cancer Program, Flinders Health and Medical Research Institute, Flinders University College of Medicine and Public Health, Flinders

J Biol Chem ; 299(12): 105368, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37866634

Assuntos

Hidrocarboneto de Aril Hidroxilases; Citocromo P-450 CYP2C9; Dapsona; Flurbiprofeno; Anti-Inflamatórios não Esteroides/farmacologia; Anti-Inflamatórios não Esteroides/metabolismo; Hidrocarboneto de Aril Hidroxilases/metabolismo; Citocromo P-450 CYP2C9/genética; Citocromo P-450 CYP2C9/metabolismo; Sistema Enzimático do Citocromo P-450/metabolismo; Dapsona/metabolismo; Flurbiprofeno/metabolismo; Cinética; Naproxeno/metabolismo; Humanos

Palavras-chave

CYP2C9 activation; allosterism; computer modeling; cooperativity; cytochrome P450; drug metabolism; drugdrug interaction; enzyme kinetics; molecular dynamics; molecular pharmacology

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hidrocarboneto de Aril Hidroxilases / Flurbiprofeno / Dapsona / Citocromo P-450 CYP2C9 Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google