Psychopharmacological impact of ferulic acid on depressive-like behaviors induced by high fat diet in rats models of depression.

ABSTRACT

Previous studies have been demonstrated that high fat diet can leads to the development of obesity. Obesity is strongly linked with several kinds of neurological and physiological disorders such as type 2 diabetes and cardiovascular diseases. Furthermore studies also suggested that obesity may cause behavioral changes that mainly deal with less locomotor activity and anxiety obesity linked behavioral changes induced by HFD. By using different parameters like growth rate, food intake, levels of anxiety and locomotor activity the finding of this study showed that, that repeated administration of ferulic acid has great profound effect on impairments that were caused by HFD. In our experiments we have observed that those rats which were on HFD and were treated with water only was seemed to be more depressed, less active, and more anxious than those which were administered by ferulic acid doses. From these results we can also suggest that there must be disturbance in the levels of neurotransmitters in an obese individual that caused such kind of changes in the body. This study has implications in the recovery of the changes in the body that were produced by HFD. And ferulic acid can be used as the drug to cure behavioral consequences that were induced by HFD.