T1-/T2-weighted ratio reveals no alterations to gray matter myelination in temporal lobe epilepsy.
Ann Clin Transl Neurol
; 10(11): 2149-2154, 2023 11.
Article
em En
| MEDLINE
| ID: mdl-37872734
ABSTRACT
Short-range functional connectivity in the limbic network is increased in patients with temporal lobe epilepsy (TLE), and recent studies have shown that cortical myelin content correlates with fMRI connectivity. We thus hypothesized that myelin may increase progressively in the epileptic network. We compared T1w/T2w gray matter myelin maps between TLE patients and age-matched controls and assessed relationships between myelin and aging. While both TLE patients and healthy controls exhibited increased T1w/T2w intensity with age, we found no evidence for significant group-level aberrations in overall myelin content or myelin changes through time in TLE.
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Base de dados:
MEDLINE
Assunto principal:
Epilepsia do Lobo Temporal
/
Substância Cinzenta
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article