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Exploring the emotional and behavioural profile in paediatric narcolepsy type 1: A case-control study.
Simoncini Malucelli, Giorgia; Mercante, Anna; Pizza, Fabio; Brunetti, Valerio; Biscarini, Francesco; Vandi, Stefano; Mazzoni, Alice; Franceschini, Christian; Della Marca, Giacomo; Vollono, Catello; Chieffo, Daniela Pia Rosaria; Plazzi, Giuseppe.
Afiliação
  • Simoncini Malucelli G; Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Mercante A; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Pizza F; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Brunetti V; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Biscarini F; Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
  • Vandi S; UOC di Neurologia - Dipartimento di Scienze dell'Invecchiamento, Neurologiche, Ortopediche e della Testa-Collo, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy.
  • Mazzoni A; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Franceschini C; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Della Marca G; Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
  • Vollono C; IRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
  • Chieffo DPR; Department of Medicine and Surgery, University of Parma, Parma, Italy.
  • Plazzi G; Department of Neurosciences, Università Cattolica del Sacro Cuore, Rome, Italy.
J Sleep Res ; : e14064, 2023 Oct 23.
Article em En | MEDLINE | ID: mdl-37872846
Narcolepsy type 1 (NT1) is a central disorder of hypersomnolence often arising in childhood and adolescence. NT1 has a significant, but poorly defined, psychological impact. We aimed to investigate the psycho-social functioning of children and adolescents with NT1. We performed a cross-sectional, child and parent-reported questionnaire survey in 37 children and adolescents (6-17 years) with NT1, compared with age- and sex-matched controls. Questionnaires (SSHS, ESS-CHAD, CDI, MASC, CBCL, CRS-R, and SNAP-IV) evaluated various aspects of behavioural and emotional profiles, sleep habits, and daytime sleepiness. Subsequently, NT1 intra-group analysis was performed to investigate the effect of sex (males vs females) and pharmacological treatment (treated vs non-treated) on psychological features. The NT1 questionnaires total scores were then correlated with the clinical characteristics (age, body mass index [BMI], ESS-CHAD score, cerebrospinal hypocretin-1 [Hcrt-1] levels, and diagnostic delay). Patients with NT1 showed a higher tendency to depressive symptoms, anxiety, somatisation, inattention, hyperactivity, oppositional/defiant problems, and other maladaptive behaviours compared with controls. Among NT1 patients, females showed a higher propensity to anxiety, and non-treated patients displayed higher depressive symptoms. Psychological symptoms increased with age, BMI, and daytime sleepiness in patients with NT1, while a younger age was associated with more frequent somatisation symptoms. Lower cerebrospinal Hcrt-1 levels correlated with poorer social competencies, daily activities, and inattention. Diagnostic delay was associated with a higher impact of depressive symptoms and behavioural problems. NT1 in children and adolescents is associated with poorer functioning in multiple psychological domains calling for a multidisciplinary approach and monitoring to reduce disease burden and to prevent psychiatric consequences.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article