scAAV9-VEGF alleviates symptoms of amyotrophic lateral sclerosis (ALS) mice through regulating aromatase.

Wang, Ying; Sun, Shuo; Zhai, Jingxu; Liu, Yuanyuan; Song, Chaoyuan; Sun, Cuimei; Li, Qiang; Liu, Jianqiang; Jiang, Hong; Liu, Yaling

Wang, Ying; Sun, Shuo; Zhai, Jingxu; Liu, Yuanyuan; Song, Chaoyuan; Sun, Cuimei; Li, Qiang; Liu, Jianqiang; Jiang, Hong; Liu, Yaling.

Afiliação

Wang Y; West Department of Neurology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo, 255036, Shandong, People's Republic of China.
Sun S; Department of Neurosurgery, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo, 255036, Shandong, People's Republic of China.
Zhai J; The Third Department of Pediatrics, Xingtai People's Hospital, 16 Hongxing Street, Xingtai, Hebei, People's Republic of China.
Liu Y; General practice department, Cangzhou Central Hospital, 16 Xinhua West Road, Cangzhou, Hebei, People's Republic of China.
Song C; West Department of Neurology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo, 255036, Shandong, People's Republic of China.
Sun C; West Department of Neurology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo, 255036, Shandong, People's Republic of China.
Li Q; West Department of Neurology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo, 255036, Shandong, People's Republic of China.
Liu J; West Department of Neurology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo, 255036, Shandong, People's Republic of China.
Jiang H; West Department of Neurology, Zibo Central Hospital, No. 54 Gongqingtuan West Road, Zibo, 255036, Shandong, People's Republic of China.
Liu Y; Department of Neurology, The Second Hospital of Hebei Medical University, 215 West Heping Road, Shijiazhuang, Hebei, People's Republic of China. lyldoctor@163.com.

Exp Brain Res ; 241(11-12): 2817-2827, 2023 Dec.

Article em En | MEDLINE | ID: mdl-37882882

Assuntos

Esclerose Lateral Amiotrófica; Doenças Neurodegenerativas; Camundongos; Animais; Esclerose Lateral Amiotrófica/tratamento farmacológico; Esclerose Lateral Amiotrófica/metabolismo; Neurônios Motores/fisiologia; Fator A de Crescimento do Endotélio Vascular/metabolismo; Fator A de Crescimento do Endotélio Vascular/farmacologia; Doenças Neurodegenerativas/metabolismo; Aromatase/genética; Aromatase/metabolismo; Aromatase/farmacologia; Superóxido Dismutase/genética; Superóxido Dismutase/metabolismo; Superóxido Dismutase/farmacologia; Camundongos Transgênicos; Modelos Animais de Doenças; Estrogênios/farmacologia; Estrogênios/uso terapêutico

Palavras-chave

Amyotrophic lateral sclerosis; Autophagy; Estrogen; Oxidative stress; VEGF

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Esclerose Lateral Amiotrófica Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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