Gold Catalyzed 7-endo-dig Hydroaminations Yielding 1,4-Diazepineones.
J Org Chem
; 88(22): 15975-15982, 2023 Nov 17.
Article
em En
| MEDLINE
| ID: mdl-37890169
ABSTRACT
Strategies to access the 1,4-diazepindiones heterocyclic core of the TAN-1057 family of natural products revealed a successful gold-catalyzed hydroamination of yneamide tethered amines. The precursor amino-yneamides are derived from easily accessible 1,2-diamines and alkynoic acids and are efficiently cyclized to the corresponding diazepineones.
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Base de dados:
MEDLINE
Idioma:
En
Ano de publicação:
2023
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Article