Histopathological Gap in Aortic Diseases: A Prospective Analysis.
Int J Mol Sci
; 24(20)2023 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-37895149
ABSTRACT
Aortic dissection (AD) is a critical cardiovascular condition with the potential for devastating consequences. This study evaluated the histological changes in the aorta wall in patients with AD and aortic aneurysm (AA) who received surgical aortic replacement. Histopathological data showed that modifications of the media layer (p = 0.0197), myxomatous aspect (p = 0.0001), and subendothelial layer degeneration (p = 0.0107) were more frequently seen in AA versus AD samples. Patients with AA were approximately twice as likely to develop histological changes than those with AD (p = 0.0037). Patients with moderate or severe medial degeneration had a higher chance of developing AD (p = 0.0001). Because the histopathological score proved to be a predictor of both in-hospital and overall mortality, its evaluation should become the standard of care in any patients who undergo aortic replacement. Individualized postoperative management might be influenced by the histopathological aspect of the aortic layer.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Aneurisma Aórtico
/
Doenças da Aorta
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Arteriosclerose
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Dissecção Aórtica
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article