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Mechanistic Intimate Insights into the Role of Hydrogen Sulfide in Alzheimer's Disease: A Recent Systematic Review.
Munteanu, Constantin; Iordan, Daniel Andrei; Hoteteu, Mihail; Popescu, Cristina; Postoiu, Ruxandra; Onu, Ilie; Onose, Gelu.
Afiliação
  • Munteanu C; Faculty of Medical Bioengineering, University of Medicine and Pharmacy "Grigore T. Popa", 700454 Iași, Romania.
  • Iordan DA; Teaching Emergency Hospital "Bagdasar-Arseni" (TEHBA), 041915 Bucharest, Romania.
  • Hoteteu M; Department of Individual Sports and Kinetotherapy, Faculty of Physical Education and Sport, 'Dunarea de Jos' University of Galati, 800008 Galati, Romania.
  • Popescu C; Teaching Emergency Hospital "Bagdasar-Arseni" (TEHBA), 041915 Bucharest, Romania.
  • Postoiu R; Teaching Emergency Hospital "Bagdasar-Arseni" (TEHBA), 041915 Bucharest, Romania.
  • Onu I; Faculty of Medicine, University of Medicine and Pharmacy "Carol Davila" (UMPCD), 020022 Bucharest, Romania.
  • Onose G; Teaching Emergency Hospital "Bagdasar-Arseni" (TEHBA), 041915 Bucharest, Romania.
Int J Mol Sci ; 24(20)2023 Oct 23.
Article em En | MEDLINE | ID: mdl-37895161
In the rapidly evolving field of Alzheimer's Disease (AD) research, the intricate role of Hydrogen Sulfide (H2S) has garnered critical attention for its diverse involvement in both pathological substrates and prospective therapeutic paradigms. While conventional pathophysiological models of AD have primarily emphasized the significance of amyloid-beta (Aß) deposition and tau protein hyperphosphorylation, this targeted systematic review meticulously aggregates and rigorously appraises seminal contributions from the past year elucidating the complex mechanisms of H2S in AD pathogenesis. Current scholarly literature accentuates H2S's dual role, delineating its regulatory functions in critical cellular processes-such as neurotransmission, inflammation, and oxidative stress homeostasis-while concurrently highlighting its disruptive impact on quintessential AD biomarkers. Moreover, this review illuminates the nuanced mechanistic intimate interactions of H2S in cerebrovascular and cardiovascular pathology associated with AD, thereby exploring avant-garde therapeutic modalities, including sulfurous mineral water inhalations and mud therapy. By emphasizing the potential for therapeutic modulation of H2S via both donors and inhibitors, this review accentuates the imperative for future research endeavors to deepen our understanding, thereby potentially advancing novel diagnostic and therapeutic strategies in AD.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Sulfeto de Hidrogênio Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Alzheimer / Sulfeto de Hidrogênio Tipo de estudo: Systematic_reviews Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article