How to recognize and manage skin toxicities associated with immune checkpoint inhibitors: a practical approach.
Br J Dermatol
; 189(Suppl 1): i3-i10, 2023 10 30.
Article
em En
| MEDLINE
| ID: mdl-37903072
ABSTRACT
Immune checkpoint inhibitors (ICIs) have revolutionized treatment strategies in the field of oncology. Their favourable outcomes in terms of efficacy and side-effect profile can be thwarted by the development of immune-related adverse events (irAEs). Cutaneous irAEs are relatively common in patients undergoing immunotherapy and include common inflammatory dermatoses (e.g. eczematous, psoriasiform and lichenoid phenotypes), maculopapular eruptions, pruritus and immunobullous disorders. Most of these reactions can be managed without ICIs having to be stopped completely; however, there are some life-threatening toxicities that dermatologists and oncologists should be aware of. In this review, we focus on how to recognize the commonly associated cutaneous irAEs, touching upon rarer reactions and red flags; finally, we provide guidance on their management.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dermatopatias
/
Exantema
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Neoplasias
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article