Highly Reproducible Quantitative Proteomics Analysis of Pancreatic Cancer Cells Reveals Proteome-Level Effects of a Novel Combination Drug Therapy That Induces Cancer Cell Death via Metabolic Remodeling and Activation of the Extrinsic Apoptosis Pathway.

Rasam, Sailee; Lin, Qingxiang; Shen, Shichen; Straubinger, Robert M; Qu, Jun

Rasam, Sailee; Lin, Qingxiang; Shen, Shichen; Straubinger, Robert M; Qu, Jun.

Afiliação

Rasam S; Department of Biochemistry, University at Buffalo, Buffalo, New York 14260, United States.
Lin Q; New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, New York 14203, United States.
Shen S; Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, New York 14260, United States.
Straubinger RM; Department of Cell Stress Biology, Roswell Park Comprehensive Cancer Center, Elm and Carlton Streets, Buffalo, New York 14203, United States.
Qu J; New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, New York 14203, United States.

J Proteome Res ; 22(12): 3780-3792, 2023 12 01.

Article em En | MEDLINE | ID: mdl-37906173

Assuntos

Neoplasias Pancreáticas; Proteoma; Humanos; Proteoma/análise; Proteômica/métodos; Neoplasias Pancreáticas/tratamento farmacológico; Neoplasias Pancreáticas/metabolismo; Gencitabina; Peptídeos/análise; Apoptose; Quimioterapia Combinada; Combinação de Medicamentos; Linhagem Celular Tumoral; Neoplasias Pancreáticas

Palavras-chave

MS1-based quantitation; UHR-IonStar; chemotherapy; pancreatic ductal adenocarcinoma; proteomics

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Proteoma Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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