A predictive nomogram developed and validated for gastric cancer patients with triple-negative tumor markers.
Future Oncol
; 20(14): 919-934, 2024 May.
Article
em En
| MEDLINE
| ID: mdl-37920954
ABSTRACT
Aim:
To predict the prognosis of gastric cancer patients with triple-negative tumor markers. Materials &methods:
Prognostic factors of the nomogram were identified through univariate and multivariate Cox regression analyses. Calibration and receiver operating characteristic curves were used to assess accuracy. Decision curve analysis and concordance indexes were utilized to compare the nomogram with the pathological tumor, node, metastasis stage.Results:
A nomogram incorporating log odds of positive lymph nodes, tumor size and lymphocyte-to-monocyte ratio was constructed. The calibration and receiver operating characteristic curves (area under the curve >0.85) showed high accuracy in predicting overall survival. The concordance indexes (0.832 vs 0.760; p < 0.001) and decision curve analysis demonstrated that the nomogram was superior to the pathological tumor, node, metastasis stage.Conclusion:
A prediction and risk stratification nomogram has been developed and validated for gastric cancer patients with triple-negative tumor markers.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article