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Druggable site near the upper vestibule determines the high affinity and P2X3 homotrimer selectivity of sivopixant/S-600918 and its analogue DDTPA.
Wang, Dong-Ping; Zhang, Meng; Li, Ming; Yang, Xiao-Na; Li, Changzhu; Cao, Peng; Zhu, Michael X; Tian, Yun; Yu, Ye; Lei, Yun-Tao.
Afiliação
  • Wang DP; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China.
  • Zhang M; School of Sciences and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
  • Li M; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China.
  • Yang XN; School of Sciences and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
  • Li C; School of Sciences and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
  • Cao P; College of Bioscience and Biotechnology, Hunan Agricultural University, Changsha, China.
  • Zhu MX; School of Sciences and State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing, China.
  • Tian Y; State Key Laboratory of Utilization of Woody Oil Resource, Hunan Academy of Forestry, Changsha, China.
  • Yu Y; Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China.
  • Lei YT; Department of Integrative Biology and Pharmacology, McGovern Medical School, The University of Texas Health Science Center at Houston, Houston, Texas, USA.
Br J Pharmacol ; 181(8): 1203-1220, 2024 Apr.
Article em En | MEDLINE | ID: mdl-37921202
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Triazinas / Carcinoma de Células Renais / Benzenossulfonamidas / Neoplasias Renais / Compostos de Anilina Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Pirimidinas / Triazinas / Carcinoma de Células Renais / Benzenossulfonamidas / Neoplasias Renais / Compostos de Anilina Limite: Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article