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A ribose-functionalized NAD+ with versatile activity for ADP-ribosylation.
Stephens, Elisa N; Zhang, Xiao-Nan; Lam, Albert T; Li, Jiawei; Pei, Hua; Louie, Stan G; Wang, Clay C C; Zhang, Yong.
Afiliação
  • Stephens EN; Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA. yongz@usc.edu.
  • Zhang XN; Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA. yongz@usc.edu.
  • Lam AT; Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA. yongz@usc.edu.
  • Li J; Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA. yongz@usc.edu.
  • Pei H; Titus Family Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • Louie SG; Titus Family Department of Clinical Pharmacy, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA.
  • Wang CCC; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.
  • Zhang Y; Department of Pharmacology and Pharmaceutical Sciences, Alfred E. Mann School of Pharmacy and Pharmaceutical Sciences, University of Southern California, Los Angeles, CA 90089, USA. yongz@usc.edu.
Chem Commun (Camb) ; 59(93): 13843-13846, 2023 Nov 21.
Article em En | MEDLINE | ID: mdl-37921487
ABSTRACT
An NAD+ featuring an adenosyl 4'-azido functions as a general substrate for poly-ADP-ribose polymerases. Its derived mono- and poly-ADP-ribosylated proteins can be adequately recognized by distinct ADP-ribosylation-specific readers. This molecule represents the first ribose-functionalized NAD+ with versatile activities across different ADP-ribosyltransferases and provides insight into developing new probes for ADP-ribosylation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribose / NAD Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ribose / NAD Idioma: En Ano de publicação: 2023 Tipo de documento: Article