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Anti-Inflammatory Phomalones from the Deep-Sea-Derived Fungus Trichobotrys effuse FS522.
Huang, Hui-Bin; Chen, Yu-Chan; Wen, Ting-Yue; Li, Sai-Ni; Liu, Zhao-Ming; Zhang, Wei-Min; Gao, Xiao-Xia.
Afiliação
  • Huang HB; School of Pharmacy, Guangdong Pharmaceutical University, 280 Huandong Road, University City, Panyu District Guangzhou, 510006, China.
  • Chen YC; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology South China State Key Laboratory of Applied Microbiology, 100 Central Xianlie Road, Yuexiu District, Guangzhou, 510070, China.
  • Wen TY; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology South China State Key Laboratory of Applied Microbiology, 100 Central Xianlie Road, Yuexiu District, Guangzhou, 510070, China.
  • Li SN; School of Pharmacy, Guangdong Pharmaceutical University, 280 Huandong Road, University City, Panyu District Guangzhou, 510006, China.
  • Liu ZM; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology South China State Key Laboratory of Applied Microbiology, 100 Central Xianlie Road, Yuexiu District, Guangzhou, 510070, China.
  • Zhang WM; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology South China State Key Laboratory of Applied Microbiology, 100 Central Xianlie Road, Yuexiu District, Guangzhou, 510070, China.
  • Gao XX; Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Guangdong Institute of Microbiology South China State Key Laboratory of Applied Microbiology, 100 Central Xianlie Road, Yuexiu District, Guangzhou, 510070, China.
Chem Biodivers ; 20(12): e202301512, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37921566
Four new phomalones A-D (1-4), together with five known analogues (5-9) were isolated from the deep-sea-derived fungus Trichobotrys effuse FS522. Their structures of the new compounds established by analysis of their NMR and HR-ESI-MS spectroscopic data, and the absolute configurations of 2 was determined by electronic circular dichroism (ECD) calculations. compounds 4, 6 and 8 substantially inhibited the production of nitric oxide (NO) with IC50 values of 4.64, 13.90, and 34.07 µM.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ascomicetos Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ascomicetos Idioma: En Ano de publicação: 2023 Tipo de documento: Article