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Investigation of mechanisms of action involved in the antidepressant-like effect of Trans,trans-farnesol in mice.
Delmondes, Gyllyandeson de Araújo; Pereira Lopes, Maria Janice; Borges, Alex de Sousa; Bezerra, Daniel Souza; Silva, Jairo Pessoa da; Souto, Bruna Silva; Costa, Jadson Galdino da Silva; Campos, Paula Eloíse de Sousa; Santana, Temistocles Italo de; Coutinho, Henrique Douglas Melo; Barbosa-Filho, José Maria; Alencar de Menezes, Irwin Rose; Bezerra Felipe, Cícero Francisco; Kerntopf, Marta Regina.
Afiliação
  • Delmondes GA; Postgraduate Program in Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil; Nursing Collegiate, Federal University of São Francisco Valley, Petrolina, PE, Brazil. Electronic address: gyllyandesondelmondes@gmail.com.
  • Pereira Lopes MJ; Natural Products Pharmacology Laboratory, Regional University of Cariri, Crato, CE, Brazil.
  • Borges AS; Postgraduate Program in Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Bezerra DS; Postgraduate Program in Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil; Natural Products Pharmacology Laboratory, Regional University of Cariri, Crato, CE, Brazil.
  • Silva JPD; Nursing Collegiate, Federal University of São Francisco Valley, Petrolina, PE, Brazil.
  • Souto BS; Nursing Collegiate, Federal University of São Francisco Valley, Petrolina, PE, Brazil.
  • Costa JGDS; Nursing Collegiate, Federal University of São Francisco Valley, Petrolina, PE, Brazil.
  • Campos PES; Santa Maria College (FSM), Cajazeira, PB, Brazil.
  • Santana TI; Mauricio de Nassau University Center, Petrolina, PE, Brazil.
  • Coutinho HDM; Postgraduate Program in Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Barbosa-Filho JM; Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil.
  • Alencar de Menezes IR; Postgraduate Program in Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil.
  • Bezerra Felipe CF; Federal University of Paraíba (UFPB), João Pessoa, PB, Brazil.
  • Kerntopf MR; Postgraduate Program in Biological Chemistry, Regional University of Cariri, Crato, CE, Brazil; Natural Products Pharmacology Laboratory, Regional University of Cariri, Crato, CE, Brazil.
Chem Biol Interact ; 386: 110791, 2023 Dec 01.
Article em En | MEDLINE | ID: mdl-37923004
ABSTRACT
This study aimed to investigate, through in vivo and biochemical methodologies, the effect of trans,trans-farnesol (12.5, 25, 50 or 100 mg/kg, p.o.) acute administration, adopting different behavioral and neurochemical parameters associated with an acute induced-depression model in mice. The initial results showed that, the oral treatment with trans,trans-farnesol, at the dose of 100 mg/kg induced a possible antidepressant-like effect in animals subjected to forced swim test (FST) and reserpine-induced akinesia. In addition, it was observed that the compound in question has an effect size and properties similar to imipramine (prototype of tricyclic antidepressants), but devoid of proconvulsant adverse effect. In biochemical assays, the pretreatment with trans,trans-farnesol, at a dose of 100 mg/kg (p.o.), decreased the hippocampal concentration of thiobarbituric acid reactive substances (TBARS) and restored striatal levels of noradrenaline and serotonin in mice subjected to FST. Altogether, these results suggest that trans,trans-farnesol showed a significant antidepressant-like effect, which seems to be mediated by the antagonism of muscarinic cholinergic receptors, reduction of oxidative stress and the modulation of noradrenaline and serotonin content in the central nervous system.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serotonina / Farneseno Álcool Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Serotonina / Farneseno Álcool Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article