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Mini PROTACs: N-end rule-mediated degradation on the horizon.
Liu, Yanfen; Wang, Zhangshun; Cang, Yong.
Afiliação
  • Liu Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. Electronic address: liuyf@shanghaitech.edu.cn.
  • Wang Z; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China.
  • Cang Y; School of Life Science and Technology, ShanghaiTech University, Shanghai, 201210, China. Electronic address: cangyong@shanghaitech.edu.cn.
Trends Biochem Sci ; 49(1): 5-7, 2024 01.
Article em En | MEDLINE | ID: mdl-37923612
Heterobifunctional proteolysis-targeting chimeras (PROTACs) offer a promising cancer treatment avenue by efficiently degrading unwanted cellular proteins. A recent study from Zhang et al. demonstrated the successful utilization of the N-end rule in PROTAC design, allowing for a modular degradation rate tailored to the oncogenic driver BCR-ABL.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas / Ubiquitina-Proteína Ligases Idioma: En Ano de publicação: 2024 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas / Ubiquitina-Proteína Ligases Idioma: En Ano de publicação: 2024 Tipo de documento: Article