Net survival in colon and rectal cancer by stage according to neoadjuvant treatment. A French population-based study.

Jooste, Valérie; Grosclaude, Pascale; Defossez, Gautier; Daubisse, Laetitia; Woronoff, Anne-Sophie; Bouvier, Véronique; Chirpaz, Emmanuel; Tretarre, Brigitte; Lapotre, Bénédicte; Plouvier, Sandrine; Launoy, Guy; Bonneault, Mélanie; Molinié, Florence; Bouvier, Anne-Marie

Jooste, Valérie; Grosclaude, Pascale; Defossez, Gautier; Daubisse, Laetitia; Woronoff, Anne-Sophie; Bouvier, Véronique; Chirpaz, Emmanuel; Tretarre, Brigitte; Lapotre, Bénédicte; Plouvier, Sandrine; Launoy, Guy; Bonneault, Mélanie; Molinié, Florence; Bouvier, Anne-Marie.

Afiliação

Jooste V; Digestive Cancer Registry of Burgundy, Dijon, France; Dijon University Hospital, Dijon, France; INSERM UMR 1231 EPICAD, Dijon, France; University of Burgundy, Dijon, France; FRANCIM Network, Toulouse F-31073, France.
Grosclaude P; FRANCIM Network, Toulouse F-31073, France; Tarn Cancer Registry, Claudius Regaud Institute, IUCT-O, Toulouse, France; CERPOP INSERM U1295, Toulouse III University, F-31000, France.
Defossez G; FRANCIM Network, Toulouse F-31073, France; Registre général des cancers de Poitou-Charentes, Poitiers University Hospital, France; INSERM Centre d'Investigation Clinique CIC1402, Poitiers, France.
Daubisse L; FRANCIM Network, Toulouse F-31073, France; Tarn Cancer Registry, Claudius Regaud Institute, IUCT-O, Toulouse, France; CERPOP INSERM U1295, Toulouse III University, F-31000, France.
Woronoff AS; FRANCIM Network, Toulouse F-31073, France; Doubs Cancer Registry, Besançon University Hospital, Besançon, France; Research Unit EA3181, Franche-Comté University, Besançon, France.
Bouvier V; FRANCIM Network, Toulouse F-31073, France; ANTICIPE U1086 INSERM-UCN, Centre François Baclesse, Normandie UNICAEN university, Caen, France; Calvados Digestive Cancer Registry, University Hospital Centre, Caen, France.
Chirpaz E; FRANCIM Network, Toulouse F-31073, France; INSERM, CIC 1410, Reunion University Hospital, Saint-Pierre, France; Cancer Registry of Reunion Island, Reunion University Hospital, Saint-Denis, France.
Tretarre B; FRANCIM Network, Toulouse F-31073, France; CERPOP INSERM U1295, Toulouse III University, F-31000, France; Registre des Tumeurs de l'Hérault, Montpellier, France.
Lapotre B; FRANCIM Network, Toulouse F-31073, France; Registre du cancer de la Somme, Amiens-Picardie University Hospital, Amiens, France; CHIMERE, Chirurgie, imagerie et régénération tissulaire de l'extrémité céphalique - Caractérisation morphologique et fonctionnelle, UR UPJV 7516, Amiens, France.
Plouvier S; FRANCIM Network, Toulouse F-31073, France; Registre général des cancers de Lille et de sa région, GCS C2RC, Lille, France.
Launoy G; FRANCIM Network, Toulouse F-31073, France; ANTICIPE U1086 INSERM-UCN, Centre François Baclesse, Normandie UNICAEN university, Caen, France; Calvados Digestive Cancer Registry, University Hospital Centre, Caen, France.
Bonneault M; FRANCIM Network, Toulouse F-31073, France; Isere Cancer Registry, University Hospital Grenoble-Alpes, Grenoble, France.
Molinié F; FRANCIM Network, Toulouse F-31073, France; CERPOP INSERM U1295, Toulouse III University, F-31000, France; Registre des Cancers de Loire-Atlantique et Vendee, Nantes University Hospital, France.
Bouvier AM; Digestive Cancer Registry of Burgundy, Dijon, France; Dijon University Hospital, Dijon, France; INSERM UMR 1231 EPICAD, Dijon, France; University of Burgundy, Dijon, France; FRANCIM Network, Toulouse F-31073, France. Electronic address: anne-marie.bouvier@u-bourgogne.fr.

Dig Liver Dis ; 2023 Nov 03.

Article em En | MEDLINE | ID: mdl-37926634

ABSTRACT

ABSTRACT

AIM:

Real-life estimations of survival by stage in colorectal cancer are scanty. We estimated population-based net survival by pathological stage and location, and for rectal cancer by patterns of evolution according to clinical and pathological stage with regard to neoadjuvant therapy.

METHOD:

Age-standardized net survival was estimated on 19,630 colorectal cancers diagnosed between 2009 and 2015.

RESULTS:

Five-year net survival was 64 % for colon and 62 % for rectal cancer. The highest absolute difference between colon and rectum was 12 % for stage II women aged 75 (91% vs. 79 %). Among patients with clinical stage III rectal cancer, 67 % no longer had pathological node involvement after neoadjuvant treatment. Survival was similar in clinical stage I, II or III and pathological stage III after neoadjuvant treatment and in pathological stage III without neoadjuvant treatment (between 67 % and 72 %). It ranged between 80 and 82 % in pathological stage II, without neoadjuvant treatment or with clinical stage I, II or III before neoadjuvant treatment. Survival ranged between 93 % and 95 % in pathological stage I, treated with surgery only or with clinical stage II or III before neoadjuvant treatment.