Improved reconstruction of crossing fibers in the mouse optic pathways with orientation distribution function fingerprinting.
Magn Reson Med
; 91(3): 1075-1086, 2024 Mar.
Article
em En
| MEDLINE
| ID: mdl-37927121
ABSTRACT
PURPOSE:
The accuracy of diffusion MRI tractography reconstruction decreases in the white matter regions with crossing fibers. The optic pathways in rodents provide a challenging structure to test new diffusion tractography approaches because of the small crossing volume within the optic chiasm and the unbalanced 91 proportion between the contra- and ipsilateral neural projections from the retina to the lateral geniculate nucleus, respectively.METHODS:
Common approaches based on Orientation Distribution Function (ODF) peak finding or statistical inference were compared qualitatively and quantitatively to ODF Fingerprinting (ODF-FP) for reconstruction of crossing fibers within the optic chiasm using in vivo diffusion MRI ( n = 18 $$ n=18 $$ healthy C57BL/6 mice). Manganese-Enhanced MRI (MEMRI) was obtained after intravitreal injection of manganese chloride and used as a reference standard for the optic pathway anatomy.RESULTS:
ODF-FP outperformed by over 100% all the tested methods in terms of the ratios between the contra- and ipsilateral segments of the reconstructed optic pathways as well as the spatial overlap between tractography and MEMRI.CONCLUSION:
In this challenging model system, ODF-Fingerprinting reduced uncertainty of diffusion tractography for complex structural formations of fiber bundles.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Imagem de Difusão por Ressonância Magnética
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Substância Branca
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article