Pathogenicity of functionally activated PD-1<sup>+</sup>CD8<sup>+</sup> cells and counterattacks by muscular PD-L1 through IFNÎ³ in myositis.

Sasaki, Hirokazu; Umezawa, Natsuka; Itakura, Takuji; Iwai, Hideyuki; Yasuda, Shinsuke

Pathogenicity of functionally activated PD-1⁺CD8⁺ cells and counterattacks by muscular PD-L1 through IFNÎ³ in myositis.

Sasaki, Hirokazu; Umezawa, Natsuka; Itakura, Takuji; Iwai, Hideyuki; Yasuda, Shinsuke.

Afiliação

Sasaki H; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Umezawa N; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Itakura T; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Iwai H; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan.
Yasuda S; Department of Rheumatology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University (TMDU), Tokyo, Japan. Electronic address: syasuda.rheu@tmd.ac.jp.

J Autoimmun ; 142: 103131, 2024 Jan.

Article em En | MEDLINE | ID: mdl-37931332

Assuntos

Linfócitos T CD8-Positivos; Polimiosite; Humanos; Animais; Camundongos; Receptor de Morte Celular Programada 1/metabolismo; Antígeno B7-H1/metabolismo; Virulência

Palavras-chave

IFNÎ³; Idiopathic inflammatory myopathies; Programmed-cell-death 1 (PD-1); Programmed-cell-death 1 ligand 1 (PD-L1); T cell exhaustion

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polimiosite / Linfócitos T CD8-Positivos Limite: Animals / Humans Idioma: En Ano de publicação: 2024 Tipo de documento: Article

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