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Direct arene trifluoromethylation enabled by promiscuous activity of fungal laccase.
Goh, Yi Ling; Long, Shi Yang Preston; Wong, Mun Fei Eddy; Tan, Lee Ling; Tiong, Elaine; Wong, Fong Tian; Liu, Zhennan.
Afiliação
  • Goh YL; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, Neuros #07-01, Singapore 138665, Republic of Singapore. liu_zhennan@isce2.a-star.edu.sg.
  • Long SYP; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, Neuros #07-01, Singapore 138665, Republic of Singapore. liu_zhennan@isce2.a-star.edu.sg.
  • Wong MFE; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, Neuros #07-01, Singapore 138665, Republic of Singapore. liu_zhennan@isce2.a-star.edu.sg.
  • Tan LL; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos #07-01, Singapore 138673, Republic of Singapore.
  • Tiong E; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos #07-01, Singapore 138673, Republic of Singapore.
  • Wong FT; Institute of Sustainability for Chemicals, Energy and Environment (ISCE2), Agency for Science, Technology and Research (A*STAR), 8 Biomedical Grove, Neuros #07-01, Singapore 138665, Republic of Singapore. liu_zhennan@isce2.a-star.edu.sg.
  • Liu Z; Institute of Molecular and Cell Biology (IMCB), Agency for Science, Technology and Research (A*STAR), 61 Biopolis Drive, Proteos #07-01, Singapore 138673, Republic of Singapore.
Org Biomol Chem ; 21(45): 8975-8978, 2023 11 22.
Article em En | MEDLINE | ID: mdl-37933470
ABSTRACT
Laccase from Trametes versicolor was found to oxidize non-phenolic arenes and enable the trifluoromethylation of arenes in the presence of in situ generated CF3 radicals at a catalyst loading as low as 0.0034%. The biocatalytic trifluoromethylation proceeded under mild conditions and could increase the yield by up to 12 fold, compared to the control.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lacase / Trametes Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Lacase / Trametes Idioma: En Ano de publicação: 2023 Tipo de documento: Article