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Interleukin-27 tackles immunosuppression in chronic lymphocytic leukemia.
Fernandez Botana, Iria; Pagano, Giulia; Moussay, Etienne; Paggetti, Jerome.
Afiliação
  • Fernandez Botana I; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg.
  • Pagano G; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
  • Moussay E; Tumor Stroma Interactions, Department of Cancer Research, Luxembourg Institute of Health, Luxembourg.
  • Paggetti J; Faculty of Science, Technology and Medicine, University of Luxembourg, Esch-sur-Alzette, Luxembourg.
Oncoimmunology ; 12(1): 2276490, 2023.
Article em En | MEDLINE | ID: mdl-37937211
ABSTRACT
Chronic lymphocytic leukemia (CLL) is the most common adult leukemia in the western world. It is characterized by a high dependency on interactions with the surrounding immune landscape, highlighting its suitability for immune-mediated therapeutic interventions. We recently revealed that the cytokine IL-27 exerts a strong anti-tumor role in CLL through a T-cell-mediated mechanism.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Interleucina-27 Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia Linfocítica Crônica de Células B / Interleucina-27 Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article