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Association of obesity with cardiovascular disease in the absence of traditional risk factors.
Luo, Hui; Liu, Yesong; Tian, Xue; Zhao, Yuhan; Liu, Lulu; Zhao, Zemeng; Luo, Lili; Zhang, Yanmin; Jiang, Xiaozhong; Liu, Yeqiang; Luo, Yanxia; Wang, Anxin.
Afiliação
  • Luo H; Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
  • Liu Y; Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
  • Tian X; Department of Neurology, Kailuan General Hospital, Tangshan, China.
  • Zhao Y; Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
  • Liu L; Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
  • Zhao Z; Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
  • Luo L; Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
  • Zhang Y; Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
  • Jiang X; Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
  • Liu Y; Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
  • Luo Y; Beijing Municipal Key Laboratory of Clinical Epidemiology, Beijing, China.
  • Wang A; Department of Epidemiology and Health Statistics, School of Public Health, Capital Medical University, Beijing, China.
Int J Obes (Lond) ; 48(2): 263-270, 2024 Feb.
Article em En | MEDLINE | ID: mdl-37938287
BACKGROUND: The association between obesity and cardiovascular disease (CVD) in people without traditional CVD risk factors is unclear. This study aimed to investigate the association of obesity with CVD and its subtypes in people without traditional CVD risk factors. METHODS: Based on the Kailuan cohort study, the included participants were divided into different groups according to levels of body mass index (BMI) and waist height ratio (WHtR), respectively. Multivariate Cox proportional hazard models were used to evaluate the associations. RESULTS: This study included 31,955 participants [men 63.99%; mean age (48.14 ± 3.33) years]. During a median follow-up period of 12.97 (interquartile range: 12.68-13.17) years, 1298 cases of CVD were observed. Compared with the normal BMI group, the hazard ratios (HRs) for CVD, stroke, and myocardial infarction (MI) in the BMI obese group were 1.31 (95% confidence interval [CI] 1.11-1.55), 1.21 (95%CI 1.01-1.46), 1.62 (95%CI 1.13-2.33), respectively. Compared with the WHtR non-obese group, the HRs for CVD, stroke, and MI in the obese group were 1.25(95%CI 1.11-1.41), 1.18 (95%CI 1.03-1.34), 1.57 (95%CI 1.18-2.09), respectively. There was an interaction between age and WHtR (P for interaction was 0.043). The association between WHtR and CVD was stronger in people under 60 years old, with a HR of 1.44 (95%CI 1.24-1.67). CONCLUSION: We found that obesity increased the risk of CVD in people without traditional CVD risk factors. The association of WHtR with CVD was stronger in people under 60 years old.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Acidente Vascular Cerebral / Infarto do Miocárdio Limite: Adult / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Cardiovasculares / Acidente Vascular Cerebral / Infarto do Miocárdio Limite: Adult / Humans / Male / Middle aged Idioma: En Ano de publicação: 2024 Tipo de documento: Article