A review for the correlation between optic atrophy 1-dependent mitochondrial fusion and cardiovascular disorders.
Int J Biol Macromol
; 254(Pt 2): 127910, 2024 Jan.
Article
em En
| MEDLINE
| ID: mdl-37939779
ABSTRACT
Mitochondrial dynamics homeostasis is sustained by continuous and balanced fission and fusion, which are determinants of morphology, abundance, biogenesis and mitophagy of mitochondria. Optic atrophy 1 (OPA1), as the only inner mitochondrial membrane fusion protein, plays a key role in stabilizing mitochondrial dynamics. The disturbance of mitochondrial dynamics contributes to the pathophysiological progress of cardiovascular disorders, which are the main cause of death worldwide in recent decades and result in tremendous social burden. In this review, we describe the latest findings regarding OPA1 and its role in mitochondrial fusion. We summarize the post-translational modifications (PTMs) for OPA1 and its regulatory role in mitochondrial dynamics. Then the diverse cell fates caused by OPA1 expression during cardiovascular disorders are discussed. Moreover, cardiovascular disorders (such as heart failure, myocardial ischemia/reperfusion injury, cardiomyopathy and cardiac hypertrophy) relevant to OPA1-dependent mitochondrial dynamics imbalance have been detailed. Finally, we highlight the potential that targeting OPA1 to impact mitochondrial fusion may be used as a novel strategy against cardiovascular disorders.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Atrofia Óptica Autossômica Dominante
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Insuficiência Cardíaca
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Cardiomiopatias
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article