Diagnostic value of niacin skin blunting response in adolescent patients with depression.
BMC Psychiatry
; 23(1): 815, 2023 11 08.
Article
em En
| MEDLINE
| ID: mdl-37940887
ABSTRACT
OBJECTIVE:
To investigate the differences in the niacin skin flushing response of adolescent depressed patients and healthy adolescents and its diagnostic value in adolescent depression.METHODS:
Thirty-eight cases of acute episodes of depression in unmedicated adolescents and 47 age- and sex-matched healthy controls were included as study subjects, and sociodemographic and clinical data were collected, all of which were stimulated with six concentration gradients (up to 60 mmol/L, followed by sequential 3-fold gradient dilution to a minimum of 0.25 mmol/L) of niacin solution on the forearm skin, and the skin flushing area was applied as an assessment index.RESULTS:
The total area of redness of the skin in response to niacin was significantly lower in the adolescent depression group than in the healthy adolescent group (Z=-3.36, p = 0.001) and was able to distinguish the adolescent depression group from the healthy adolescent group (area under curve = 0.713, sensitivity 51.1%, specificity 83.2%).CONCLUSIONS:
Niacin sensitivity is reduced in adolescent depressed patients, and the niacin skin flush response has potential clinical value as a diagnostic biomarker for adolescent depression.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Niacina
Limite:
Adolescent
/
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article