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DNA replication machineries: Structural insights from crystallography and electron microscopy.
Bocanegra, Rebeca; Ortíz-Rodríguez, María; Zumeta, Lyra; Plaza-G A, Ismael; Faro, Elías; Ibarra, Borja.
Afiliação
  • Bocanegra R; IMDEA Nanociencia, Campus Cantoblanco, Madrid, Spain.
  • Ortíz-Rodríguez M; IMDEA Nanociencia, Campus Cantoblanco, Madrid, Spain.
  • Zumeta L; IMDEA Nanociencia, Campus Cantoblanco, Madrid, Spain.
  • Plaza-G A I; IMDEA Nanociencia, Campus Cantoblanco, Madrid, Spain.
  • Faro E; IMDEA Nanociencia, Campus Cantoblanco, Madrid, Spain.
  • Ibarra B; IMDEA Nanociencia, Campus Cantoblanco, Madrid, Spain. Electronic address: borja.ibarra@imdea.org.
Enzymes ; 54: 249-271, 2023.
Article em En | MEDLINE | ID: mdl-37945174
Since the discovery of DNA as the genetic material, scientists have been investigating how the information contained in this biological polymer is transmitted from generation to generation. X-ray crystallography, and more recently, cryo-electron microscopy techniques have been instrumental in providing essential information about the structure, functions and interactions of the DNA and the protein machinery (replisome) responsible for its replication. In this chapter, we highlight several works that describe the structure and structure-function relationships of the core components of the prokaryotic and eukaryotic replisomes. We also discuss the most recent studies on the structural organization of full replisomes.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA / Replicação do DNA Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: DNA / Replicação do DNA Idioma: En Ano de publicação: 2023 Tipo de documento: Article