Factor XI/XIa inhibitors for the prevention and treatment of venous and arterial thromboembolism: A narrative review.
Vasc Med
; 29(1): 85-92, 2024 Feb.
Article
em En
| MEDLINE
| ID: mdl-37947131
ABSTRACT
During the past decade, direct oral anticoagulants (DOACs) have advanced and simplified the prevention and treatment of venous thromboembolism (VTE). However, there remains a high incidence of bleeds, which calls for agents that have a reduced risk of bleeding. Factor XI (FXI) deficiency is associated with lower rates of venous thrombosis and stroke compared to the general population with a lower risk of bleeding. In conjunction with this, phase 2 studies have demonstrated safety and the potential for reduced thrombotic events with FXI inhibitors as compared to currently available medications. The aim of this review is to summarize key data on the clinical pharmacology of FXI, the latest developments in clinical trials of FXI inhibitors, and to describe the efficacy and safety profiles of FXI inhibitors for the prevention of venous and arterial thromboembolism.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Trombose Venosa
/
Tromboembolia Venosa
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article