Asymmetric Synthesis of (+)-Vellosimine Enabled by a Sequential Nucleophilic Addition/Cyclization Process.
Org Lett
; 25(46): 8215-8219, 2023 Nov 24.
Article
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| MEDLINE
| ID: mdl-37955360
ABSTRACT
Herein, we achieved the asymmetric synthesis of (+)-vellosimine in 13 steps (longest linear sequences, LLS). This synthesis featured a sequential nucleophilic addition/cyclization process, which provided an efficient protocol for synthesizing a range of indole fused azabicyclo[3.3.1]nonane. Additionally, a SmI2-mediated reductive cyclization of ketone with an attached α,ß-unsaturated ester for constructing the strained quinuclidine moiety was also highlighted.
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MEDLINE
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En
Ano de publicação:
2023
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Article