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Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells.
Linder, Samantha J; Bernasocchi, Tiziano; Martínez-Pastor, Bárbara; Sullivan, Kelly D; Galbraith, Matthew D; Lewis, Caroline A; Ferrer, Christina M; Boon, Ruben; Silveira, Giorgia G; Cho, Hyo Min; Vidoudez, Charles; Shroff, Stuti; Oliveira-Costa, Joao P; Ross, Kenneth N; Massri, Rami; Matoba, Yusuke; Kim, Eugene; Rueda, Bo R; Stott, Shannon L; Gottlieb, Eyal; Espinosa, Joaquin M; Mostoslavsky, Raul.
Afiliação
  • Linder SJ; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
  • Bernasocchi T; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA. tbernasocchi@mgh.harvard.edu.
  • Martínez-Pastor B; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO, USA. tbernasocchi@mgh.harvard.edu.
  • Sullivan KD; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
  • Galbraith MD; Spanish National Cancer Research Center (CNIO), Madrid, Spain.
  • Lewis CA; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Ferrer CM; Section of Developmental Biology, Department of Pediatrics, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Boon R; Department of Pharmacology, University of Colorado School of Medicine, Anschutz Medical Campus, Denver, CO, USA.
  • Silveira GG; Linda Crnic Institute for Down Syndrome, University of Colorado Anschutz Medical Campus, Aurora, CO, USA.
  • Cho HM; The Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, USA.
  • Vidoudez C; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
  • Shroff S; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Oliveira-Costa JP; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
  • Ross KN; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Massri R; Galapagos de Wittelaan, Mechelen, Belgium.
  • Matoba Y; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
  • Kim E; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Rueda BR; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
  • Stott SL; The Broad Institute of Harvard and MIT, Cambridge, MA, USA.
  • Gottlieb E; Harvard Center for Mass Spectrometry, Cambridge, MA, USA.
  • Espinosa JM; Department of Pathology, The Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
  • Mostoslavsky R; The Krantz Family Center for Cancer Research, The Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA.
Nat Metab ; 5(12): 2131-2147, 2023 Dec.
Article em En | MEDLINE | ID: mdl-37957387
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glutamina / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glutamina / Neoplasias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article