Heptanoate Improves Compensatory Mechanism of Glucose Homeostasis in Mitochondrial Long-Chain Fatty Acid Oxidation Defect.

Nurjanah, Siti; Gerding, Albert; Vieira-Lara, Marcel A; Evers, Bernard; Langelaar-Makkinje, Miriam; Spiekerkoetter, Ute; Bakker, Barbara M; Tucci, Sara

Nurjanah, Siti; Gerding, Albert; Vieira-Lara, Marcel A; Evers, Bernard; Langelaar-Makkinje, Miriam; Spiekerkoetter, Ute; Bakker, Barbara M; Tucci, Sara.

Afiliação

Nurjanah S; Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Centre, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.
Gerding A; Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany.
Vieira-Lara MA; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Evers B; Laboratory of Metabolic Diseases, Department of Laboratory Medicine, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Langelaar-Makkinje M; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Spiekerkoetter U; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Bakker BM; Laboratory of Pediatrics, Systems Medicine of Metabolism and Signaling, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Tucci S; Department of General Pediatrics, Adolescent Medicine and Neonatology, Medical Centre, Faculty of Medicine, University of Freiburg, 79106 Freiburg, Germany.

Nutrients ; 15(21)2023 Nov 05.

Article em En | MEDLINE | ID: mdl-37960342

Assuntos

Hipoglicemia; Erros Inatos do Metabolismo Lipídico; Doenças Mitocondriais; Camundongos; Animais; Heptanoatos; Acil-CoA Desidrogenase de Cadeia Longa/genética; Acil-CoA Desidrogenase de Cadeia Longa/metabolismo; Glicerol; Ácidos Graxos/metabolismo; Glucose/uso terapêutico; Homeostase

Palavras-chave

VLCAD deficiency; fatty acid oxidation disorder; glucose homeostasis; glycerol; heptanoate; stable isotope; very long-chain acyl-CoA dehydrogenase

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Mitocondriais / Hipoglicemia / Erros Inatos do Metabolismo Lipídico Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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