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Identification of a small-molecule Tim-3 inhibitor to potentiate T cell-mediated antitumor immunotherapy in preclinical mouse models.
Ma, Shuaiya; Tian, Ye; Peng, Jiali; Chen, Chaojia; Peng, Xueqi; Zhao, Fabao; Li, Zhenyu; Li, Mengzhen; Zhao, Fangcheng; Sheng, Xue; Zong, Runzhe; Li, Yiquan; Zhang, Jiwei; Yu, Mingyan; Zhu, Qingfen; Tian, Xiaoyu; Li, Yuyang; Neckenig, Markus R; Liu, Huiqing; Zhan, Peng; Yue, Xuetian; Wu, Zhuanchang; Gao, Lifen; Liang, Xiaohong; Liu, Xinyong; Li, Chunyang; Ma, Chunhong.
Afiliação
  • Ma S; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Tian Y; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Peng J; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Chen C; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Peng X; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Zhao F; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Li Z; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Li M; Department of Pharmacy, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China.
  • Zhao F; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Sheng X; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Zong R; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Li Y; School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Zhang J; School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Yu M; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Zhu Q; Shandong Institute for Food and Drug Control, Jinan, Shandong 250101, P. R. China.
  • Tian X; Shandong Institute for Food and Drug Control, Jinan, Shandong 250101, P. R. China.
  • Li Y; Center for Cell Structure and Function, Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, P. R. 
  • Neckenig MR; Center for Cell Structure and Function, Institute of Biomedical Sciences, Shandong Provincial Key Laboratory of Animal Resistance Biology, Collaborative Innovation Center of Cell Biology in Universities of Shandong, College of Life Sciences, Shandong Normal University, Jinan, Shandong 250014, P. R. 
  • Liu H; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Zhan P; School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Yue X; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Wu Z; School of Basic Medical Sciences, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Gao L; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Liang X; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Liu X; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, School of Basic Medical Sciences, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Li C; Department of Medicinal Chemistry, Key Laboratory of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
  • Ma C; Key Laboratory for Experimental Teratology of Ministry of Education and Department of Histology and Embryology, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, P. R. China.
Sci Transl Med ; 15(722): eadg6752, 2023 Nov 15.
Article em En | MEDLINE | ID: mdl-37967204
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor Celular 2 do Vírus da Hepatite A / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptor Celular 2 do Vírus da Hepatite A / Neoplasias Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article