Dimeric IgA specifically disables intracellular mutated oncodrivers.
Immunity
; 56(11): 2461-2463, 2023 Nov 14.
Article
em En
| MEDLINE
| ID: mdl-37967526
ABSTRACT
A prevailing belief in the immunotherapy field has been that antibody therapy can effectively target only extracellular antigens. In this issue of Immunity, Biswas et al. demonstrate therapeutically effective targeting, neutralization, and removal of mutated oncodriver proteins from within epithelial cancer cells by treatment with pIgR-dependent, transcytosing dimeric-IgA antibodies.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Imunoglobulina A
/
Antígenos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article