Evaluation of pragmatic oxygenation measurement as a proxy for Covid-19 severity.
Nat Commun
; 14(1): 7374, 2023 11 15.
Article
em En
| MEDLINE
| ID: mdl-37968269
ABSTRACT
Choosing optimal outcome measures maximizes statistical power, accelerates discovery and improves reliability in early-phase trials. We devised and evaluated a modification to a pragmatic measure of oxygenation function, the [Formula see text] ratio. Because of the ceiling effect in oxyhaemoglobin saturation, [Formula see text] ratio ceases to reflect pulmonary oxygenation function at high [Formula see text] values. We found that the correlation of [Formula see text] with the reference standard ([Formula see text]/[Formula see text] ratio) improves substantially when excluding [Formula see text] and refer to this measure as [Formula see text]. Using observational data from 39,765 hospitalised COVID-19 patients, we demonstrate that [Formula see text] is predictive of mortality, and compare the sample sizes required for trials using four different outcome measures. We show that a significant difference in outcome could be detected with the smallest sample size using [Formula see text]. We demonstrate that [Formula see text] is an effective intermediate outcome measure in COVID-19. It is a non-invasive measurement, representative of disease severity and provides greater statistical power.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
COVID-19
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article