CD201+ fascia progenitors choreograph injury repair.
Nature
; 623(7988): 792-802, 2023 Nov.
Article
em En
| MEDLINE
| ID: mdl-37968392
ABSTRACT
Optimal tissue recovery and organismal survival are achieved by spatiotemporal tuning of tissue inflammation, contraction and scar formation1. Here we identify a multipotent fibroblast progenitor marked by CD201 expression in the fascia, the deepest connective tissue layer of the skin. Using skin injury models in mice, single-cell transcriptomics and genetic lineage tracing, ablation and gene deletion models, we demonstrate that CD201+ progenitors control the pace of wound healing by generating multiple specialized cell types, from proinflammatory fibroblasts to myofibroblasts, in a spatiotemporally tuned sequence. We identified retinoic acid and hypoxia signalling as the entry checkpoints into proinflammatory and myofibroblast states. Modulating CD201+ progenitor differentiation impaired the spatiotemporal appearances of fibroblasts and chronically delayed wound healing. The discovery of proinflammatory and myofibroblast progenitors and their differentiation pathways provide a new roadmap to understand and clinically treat impaired wound healing.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cicatrização
/
Fáscia
/
Receptor de Proteína C Endotelial
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article