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Statistical analysis plan for the LAKANA trial: a cluster-randomized, placebo-controlled, double-blinded, parallel group, three-arm clinical trial testing the effects of mass drug administration of azithromycin on mortality and other outcomes among 1-11-month-old infants in Mali.
Luoma, Juho; Adubra, Laura; Alber, Dagmar; Ashorn, Per; Ashorn, Ulla; Cloutman-Green, Elaine; Diallo, Fatoumata; Ducker, Camilla; Elovainio, Riku; Fan, Yue-Mei; Gates, Lily; Gruffudd, Gwydion; Haapaniemi, Tiia; Haidara, Fadima; Hallamaa, Lotta; Ihamuotila, Rikhard; Klein, Nigel; Martell, Owen; Sow, Samba; Vehmasto, Taru; Cheung, Yin Bun.
Afiliação
  • Luoma J; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. Juho.Luoma@tuni.fi.
  • Adubra L; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Alber D; Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Ashorn P; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Ashorn U; Department of Paediatrics, Tampere University Hospital, Tampere, Finland.
  • Cloutman-Green E; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Diallo F; Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Ducker C; Center for Vaccine Development, Bamako, Mali.
  • Elovainio R; Tro Da Ltd, Cardiff, UK.
  • Fan YM; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Gates L; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Gruffudd G; Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Haapaniemi T; Tro Da Ltd, Cardiff, UK.
  • Haidara F; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Hallamaa L; Center for Vaccine Development, Bamako, Mali.
  • Ihamuotila R; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Klein N; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
  • Martell O; Great Ormond Street Institute of Child Health, University College London, London, UK.
  • Sow S; Tro Da Ltd, Cardiff, UK.
  • Vehmasto T; Center for Vaccine Development, Bamako, Mali.
  • Cheung YB; Center for Child, Adolescent and Maternal Health Research, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland.
Trials ; 24(1): 733, 2023 Nov 15.
Article em En | MEDLINE | ID: mdl-37968741
BACKGROUND: The Large-scale Assessment of the Key health-promoting Activities of two New mass drug administration regimens with Azithromycin (LAKANA) trial in Mali aims to evaluate the efficacy and safety of azithromycin (AZI) mass drug administration (MDA) to 1-11-month-old infants as well as the impact of the intervention on antimicrobial resistance (AMR) and mechanisms of action of azithromycin. To improve the transparency and quality of this clinical trial, we prepared this statistical analysis plan (SAP). METHODS/DESIGN: LAKANA is a cluster randomized trial that aims to address the mortality and health impacts of biannual and quarterly AZI MDA. AZI is given to 1-11-month-old infants in a high-mortality setting where a seasonal malaria chemoprevention (SMC) program is in place. The participating villages are randomly assigned to placebo (control), two-dose AZI (biannual azithromycin-MDA), and four-dose AZI (quarterly azithromycin-MDA) in a 3:4:2 ratio. The primary outcome of the study is mortality among the intention-to-treat population of 1-11-month-old infants. We will evaluate relative risk reduction between the study arms using a mixed-effects Poisson model with random intercepts for villages, using log link function with person-years as an offset variable. We will model outcomes related to secondary objectives of the study using generalized linear models with considerations on clustering. CONCLUSION: The SAP written prior to data collection completion will help avoid reporting bias and data-driven analysis for the primary and secondary aims of the trial. If there are deviations from the analysis methods described here, they will be described and justified in the publications of the trial results. TRIAL REGISTRATION: ClinicalTrials.gov ID NCT04424511 . Registered on 11 June 2020.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azitromicina / Malária Limite: Humans / Infant País como assunto: Africa Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Azitromicina / Malária Limite: Humans / Infant País como assunto: Africa Idioma: En Ano de publicação: 2023 Tipo de documento: Article