Clostridioides difficile utilizes siderophores as an iron source and FhuDBGC contributes to ferrichrome uptake.
J Bacteriol
; 205(12): e0032423, 2023 12 19.
Article
em En
| MEDLINE
| ID: mdl-37971230
ABSTRACT
IMPORTANCE This study is the first example of C. difficile growing with siderophores as the sole iron source and describes the characterization of the ferric hydroxamate uptake ABC transporter (FhuDBGC). This transporter shows specificity to the siderophore ferrichrome. While not required for pathogenesis, this transporter highlights the redundancy in iron acquisition mechanisms that C. difficile uses to compete for iron during an infection.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Clostridioides difficile
/
Sideróforos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article