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Development and Pharmacochemical Characterization Discover a Novel Brain-Permeable HDAC11-Selective Inhibitor with Therapeutic Potential by Regulating Neuroinflammation in Mice.
Bai, Ping; Liu, Yan; Yang, Liuyue; Ding, Weihua; Mondal, Prasenjit; Sang, Na; Liu, Gang; Lu, Xiaoxia; Ho, Thanh Tu; Zhou, Yanting; Wu, Rui; Birar, Vishal C; Wilks, Moses Q; Tanzi, Rudolph E; Lin, Hening; Zhang, Can; Li, Weimin; Shen, Shiqian; Wang, Changning.
Afiliação
  • Bai P; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Liu Y; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Yang L; Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Ding W; The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan 610041, China.
  • Mondal P; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan 610041, China.
  • Sang N; Athinoula A. Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
  • Liu G; Department of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
  • Lu X; Department of Anesthesia, Critical Care and Pain Medicine Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts 02129, United States.
  • Ho TT; Genetics and Aging Research Unit, McCance Center for Brain Health, MassGeneral Institute for Neurodegenerative Disease, Department of Neurology, Massachusetts General Hospital, Harvard Medical School, 114 16th Street, Charlestown, Massachusetts 02129, United States.
  • Zhou Y; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Wu R; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Birar VC; Precision Medicine Center, Precision Medicine Key Laboratory of Sichuan Province, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Wilks MQ; The Research Units of West China, Chinese Academy of Medical Sciences, West China Hospital, Chengdu, Sichuan 610041, China.
  • Tanzi RE; State Key Laboratory of Respiratory Health and Multimorbidity, West China Hospital, Chengdu, Sichuan 610041, China.
  • Lin H; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
  • Zhang C; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China.
  • Li W; Department of Chemistry and Chemical Biology, Cornell University, Ithaca, New York 14853, United States.
  • Shen S; Department of Respiratory and Critical Care Medicine, Targeted Tracer Research and Development Laboratory, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
  • Wang C; Institute of Respiratory Health, Targeted Tracer Research and Development Laboratory, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China.
J Med Chem ; 66(23): 16075-16090, 2023 12 14.
Article em En | MEDLINE | ID: mdl-37972387
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neuroinflamatórias / Neuralgia Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neuroinflamatórias / Neuralgia Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article