Topographic axonal projection at single-cell precision supports local retinotopy in the mouse superior colliculus.
Nat Commun
; 14(1): 7418, 2023 Nov 16.
Article
em En
| MEDLINE
| ID: mdl-37973798
ABSTRACT
Retinotopy, like all long-range projections, can arise from the axons themselves or their targets. The underlying connectivity pattern, however, remains elusive at the fine scale in the mammalian brain. To address this question, we functionally mapped the spatial organization of the input axons and target neurons in the female mouse retinocollicular pathway at single-cell resolution using in vivo two-photon calcium imaging. We found a near-perfect retinotopic tiling of retinal ganglion cell axon terminals, with an average error below 30 µm or 2° of visual angle. The precision of retinotopy was relatively lower for local neurons in the superior colliculus. Subsequent data-driven modeling ascribed it to a low input convergence, on average 5.5 retinal ganglion cell inputs per postsynaptic cell in the superior colliculus. These results indicate that retinotopy arises largely from topographically precise input from presynaptic cells, rather than elaborating local circuitry to reconstruct the topography by postsynaptic cells.
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1
Base de dados:
MEDLINE
Assunto principal:
Retina
/
Colículos Superiores
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article