Voltage-gated potassium channels KCNQs: Structures, mechanisms, and modulations.
Biochem Biophys Res Commun
; 689: 149218, 2023 12 31.
Article
em En
| MEDLINE
| ID: mdl-37976835
ABSTRACT
KCNQ (Kv7) channels are voltage-gated, phosphatidylinositol 4,5-bisphosphate- (PIP2-) modulated potassium channels that play essential roles in regulating the activity of neurons and cardiac myocytes. Hundreds of mutations in KCNQ channels are closely related to various cardiac and neurological disorders, such as long QT syndrome, epilepsy, and deafness, which makes KCNQ channels important drug targets. During the past several years, the application of single-particle cryo-electron microscopy (cryo-EM) technique in the structure determination of KCNQ channels has greatly advanced our understanding of their molecular mechanisms. In this review, we summarize the currently available structures of KCNQ channels, analyze their special voltage gating mechanism, and discuss their activation mechanisms by both the endogenous membrane lipid and the exogenous synthetic ligands. These structural studies of KCNQ channels will guide the development of drugs targeting KCNQ channels.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome do QT Longo
/
Epilepsia
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article