Elucidating the novel mechanisms of molecular chaperones by single-molecule technologies.
Trends Biochem Sci
; 49(1): 38-51, 2024 01.
Article
em En
| MEDLINE
| ID: mdl-37980187
ABSTRACT
Molecular chaperones play central roles in sustaining protein homeostasis and preventing protein aggregation. Most studies of these systems have been performed in bulk, providing averaged measurements, though recent single-molecule approaches have provided an in-depth understanding of the molecular mechanisms of their activities and structural rearrangements during substrate recognition. Chaperone activities have been observed to be substrate specific, with some associated with ATP-dependent structural dynamics and others via interactions with co-chaperones. This Review aims to describe the novel mechanisms of molecular chaperones as revealed by single-molecule approaches, and to provide insights into their functioning and its implications for protein homeostasis and human diseases.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Dobramento de Proteína
/
Chaperonas Moleculares
Limite:
Humans
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article